Should we use large scale healthcare interventions without clear evidence that benefits outweigh costs and harms? No

Thiazolidinediones: do harms outweigh benefits?

Benefits, harms and evidence – reflections from UK primary healthcare

In this paper I examine the relationship between benefits, harms and evidence-based medicine in the context of British primary healthcare. First, I will examine: 'What is a benefit and what is a harm?' Second, what should we know about where the balance of risk and benefit appear to lie? Third, what should we do with this knowledge, particularly in the context of the biopsychosocial gaze of pri...

Benefits of open and high-powered research outweigh costs.

Several researchers recently outlined unacknowledged costs of open science practices, arguing these costs may outweigh benefits and stifle discovery of novel findings. We scrutinize these researchers' (a) statistical concern that heightened stringency with respect to false-positives will increase false-negatives and (b) metascientific concern that larger samples and executing direct replication...

Benefits of Rebuilding Global Marine Fisheries Outweigh Costs

Global marine fisheries are currently underperforming, largely due to overfishing. An analysis of global databases finds that resource rent net of subsidies from rebuilt world fisheries could increase from the current negative US$13 billion to positive US$54 billion per year, resulting in a net gain of US$600 to US$1,400 billion in present value over fifty years after rebuilding. To realize thi...

Functional Outcome Analysis: Do the Costs Outweigh the Benefits?